Overview

BPC-157 (Body Protection Compound-157) is a stable gastric pentadecapeptide composed of 15 amino acids. First isolated from gastric juice, it has demonstrated protective and healing effects across multiple organ systems in preclinical studies.

Mechanism of Action

Angiogenesis promotion — Upregulates VEGF expression, promoting new blood vessel formation at injury sites
Nitric oxide modulation — Interacts with the NO system to support vascular function and tissue repair
Collagen synthesis — Stimulates fibroblast activity and collagen production
Neuroprotective effects — Demonstrates CNS protection in various injury models
Gut-brain axis — Modulates dopaminergic and serotonergic systems

Clinical Applications

Musculoskeletal

Tendon and ligament repair
Muscle recovery acceleration
Bone healing support

Gastrointestinal

Gastric ulcer protection
Intestinal barrier integrity
IBD symptom management

Neurological

Peripheral nerve repair
CNS injury recovery (preclinical)

Dosing Protocols

| Protocol | Dose | Frequency | Route | |----------|------|-----------|-------| | Standard | 250mcg | Twice daily | Subcutaneous | | Acute injury | 500mcg | Twice daily | Subcutaneous, local | | Maintenance | 250mcg | Once daily | Oral (stable in GI) |

Safety Profile

BPC-157 has demonstrated a favorable safety profile in available preclinical data. No significant toxicity has been reported at standard dosing ranges. Human clinical trial data remains limited.

Key References

All claims reference primary literature available on PubMed. Clinicians should verify dosing and indications against current published research before prescribing.