Cell Surface Thiol-Disulfide Regulation in Cancer: Peptide-Based Theranostic Strategies
Lühle J, Seeberger PH, Moscovitz O
Summary
This comprehensive review examines how cancer cells exploit surface redox states to promote invasion and metastasis, and evaluates peptide-based targeting strategies including cyclic oligochalcogenides, cell-penetrating polydisulfides, and redox-sensitive antibodies for selective drug delivery to tumors.
Clinical Significance
Highlights the emerging field of redox-responsive peptide therapeutics in oncology. These strategies could enable next-generation cancer theranostics that leverage tumor-specific surface chemistry rather than relying solely on antigen targeting, expanding the peptide toolbox for precision oncology.
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