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Tesamorelin

Tesamorelin dosing, mechanism of action, side effects, and visceral fat reduction. FDA-approved Egrifta clinical reference.

Growth HormoneSubcutaneous injection2mg daily

Overview

Tesamorelin is a synthetic GHRH analog FDA-approved for reducing excess abdominal fat in HIV-associated lipodystrophy (Egrifta).

Mechanism of Action

  • GHRH receptor agonism — Stimulates pituitary GH release
  • Visceral fat reduction — Specifically targets abdominal/visceral adipose tissue
  • IGF-1 elevation — Increases insulin-like growth factor 1
  • Lipid improvement — Reduces triglycerides

Dosing

2mg subcutaneously once daily. FDA-approved dosing for lipodystrophy.

Safety

FDA-approved with extensive clinical data. Monitor glucose and IGF-1 levels.

Last updated: 2026-03-27