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GHK-Cu

GHK-Cu copper peptide benefits, dosing, mechanism of action, and wound healing properties. Anti-aging skincare reference.

Skin & Anti-AgingTopical, subcutaneous injection, mesotherapy/microneedlingTopical: 1-3% concentration; Injectable: 1-2mg

Overview

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper-binding peptide with demonstrated wound healing, anti-aging, and tissue remodeling properties.

Mechanism of Action

  • Collagen synthesis — Stimulates production of collagen, elastin, and glycosaminoglycans
  • Wound healing — Accelerates tissue repair and reduces scarring
  • Anti-inflammatory — Modulates inflammatory cytokines
  • Antioxidant — Copper-mediated free radical scavenging
  • Gene expression — Modulates expression of thousands of genes related to tissue repair

Dosing Protocols

| Application | Concentration/Dose | Route | |-------------|-------------------|-------| | Topical skincare | 1-3% in serum/cream | Topical | | Wound healing | 1-2mg | Subcutaneous near wound | | Skin rejuvenation | 1mg | Microneedling/mesotherapy |

Safety Profile

Excellent safety profile. Naturally present in human plasma. Well tolerated in topical and injectable forms.

Last updated: 2026-03-27