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NAD+ (Nicotinamide Adenine Dinucleotide)

NAD+ (Nicotinamide Adenine Dinucleotide) dosing, mechanism of action, side effects, and clinical evidence. Complete reference for healthcare professionals.

Hormone OptimizationIV infusion, subcutaneous injection500-1000mg IV or 100mg subcutaneously

Overview

NAD+ is a critical coenzyme involved in cellular metabolism, DNA repair, and sirtuin activation. Levels decline significantly with age.

Mechanism of Action

  • SIRT1 activation — Activates sirtuins for longevity pathways
  • DNA repair — Essential substrate for PARP enzymes
  • Mitochondrial function — Supports electron transport chain
  • Cellular energy — Critical for NAD+/NADH redox reactions

Dosing

IV: 500-1000mg over 2-4 hours. Subcutaneous: 100mg daily. Oral precursors (NMN/NR) also used.

Last updated: 2026-03-27