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AOD-9604

AOD-9604 dosing, fat loss mechanism, side effects, and clinical evidence. GH fragment 177-191 weight loss reference.

Weight LossSubcutaneous injection (oral formulation also investigated)300mcg daily

Overview

AOD-9604 is a modified fragment of human growth hormone (hGH fragment 177-191) studied for its fat-reducing properties without the diabetogenic or growth-promoting effects of full GH.

Mechanism of Action

  • Lipolysis stimulation — Enhances fat breakdown in adipose tissue
  • Lipogenesis inhibition — Blocks formation of new fatty acids
  • No IGF-1 elevation — Does not stimulate growth or insulin resistance
  • Cartilage repair — Some evidence of chondroprotective effects

Dosing Protocols

| Protocol | Dose | Frequency | Route | |----------|------|-----------|-------| | Standard | 300mcg | Once daily | Subcutaneous | | Loading | 500mcg | Once daily (4 weeks) | Subcutaneous |

Safety Profile

Generally well tolerated. No significant adverse effects reported in clinical trials. Does not affect blood glucose or IGF-1 levels.

Last updated: 2026-03-27