Overview

Thymosin Alpha-1 (Tα1) is a naturally occurring 28-amino acid thymic peptide that modulates immune function. Approved in 35+ countries as Zadaxin for chronic hepatitis B; used off-label in the US for immune support.

Mechanism of Action

T-cell maturation — Promotes differentiation and maturation of T-cells
Dendritic cell activation — Enhances antigen presentation
NK cell enhancement — Boosts natural killer cell activity
Antiviral activity — Potentiates interferon response
Anti-tumor — Immunomodulatory effects in oncology settings

Dosing Protocols

| Protocol | Dose | Frequency | Route | |----------|------|-----------|-------| | Immune support | 1.6mg | Twice weekly | Subcutaneous | | Hepatitis B (approved) | 1.6mg | Twice weekly (26 weeks) | Subcutaneous | | Acute illness | 1.6mg | Daily (5-7 days) | Subcutaneous |

Safety Profile

Extensive clinical data. Approved in 35+ countries. Very well tolerated. Minimal side effects — occasional injection site reactions.