HCG (Human Chorionic Gonadotropin)
HCG (Human Chorionic Gonadotropin) dosing, mechanism of action, side effects, and clinical evidence. Complete reference for healthcare professionals.
Hormone OptimizationSubcutaneous injection250-500 IU twice weekly
Overview
HCG is a glycoprotein hormone produced during pregnancy. Used clinically for fertility, maintaining testicular function during TRT, and historically in weight loss protocols.
Mechanism of Action
- LH mimicry — Binds LH receptors on testicular Leydig cells
- Testosterone stimulation — Maintains endogenous testosterone production
- Fertility preservation — Prevents testicular atrophy during exogenous testosterone use
- Ovulation induction — Triggers ovulation in fertility treatments
Dosing
For TRT adjunct: 250-500 IU subcutaneously 2x weekly. For fertility: varies by protocol.
Status
FDA-approved for multiple indications.
Last updated: 2026-03-27