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HCG (Human Chorionic Gonadotropin)

Hormone Optimization
Hormone OptimizationEvidence-based

HCG (Human Chorionic Gonadotropin)

HCG (Human Chorionic Gonadotropin) dosing, mechanism of action, side effects, and clinical evidence. Complete reference for healthcare professionals.

💉 Subcutaneous injection📊 250-500 IU twice weekly📋 FDA Approved

Last updated: 2026-03-27

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Category

Hormone Optimization

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Route

Subcutaneous injection

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Dosing

250-500 IU twice weekly

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Evidence

FDA Approved

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Availability

available

Overview

HCG is a glycoprotein hormone produced during pregnancy. Used clinically for fertility, maintaining testicular function during TRT, and historically in weight loss protocols.

Mechanism of Action

  • LH mimicry — Binds LH receptors on testicular Leydig cells
  • Testosterone stimulation — Maintains endogenous testosterone production
  • Fertility preservation — Prevents testicular atrophy during exogenous testosterone use
  • Ovulation induction — Triggers ovulation in fertility treatments

Dosing

For TRT adjunct: 250-500 IU subcutaneously 2x weekly. For fertility: varies by protocol.

Status

FDA-approved for multiple indications.

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