Obstructive Sleep Apnoea and Hypertension: GLP-1 Receptor Agonists as Emerging Therapy
Afzal M, Livesey A, Hameed MA, Mukherjee R
Summary
This review of obstructive sleep apnoea-related hypertension highlights GLP-1 receptor agonists as a promising emerging therapy alongside endothelin receptor antagonists. The authors note that GLP-1 RAs may address multiple pathophysiological mechanisms in OSA-related hypertension, including sympathetic overactivity and endothelial dysfunction, though further trials are needed.
Clinical Significance
Expands the potential therapeutic footprint of GLP-1 RAs beyond diabetes and obesity into sleep medicine and resistant hypertension. OSA affects 30-50% of hypertensive patients, and GLP-1 RAs could offer dual benefit through weight reduction and direct cardiovascular effects.
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