NAD+ (Nicotinamide Adenine Dinucleotide)

Hormone Optimization

Hormone OptimizationEvidence-based

NAD+ (Nicotinamide Adenine Dinucleotide)

NAD+ (Nicotinamide Adenine Dinucleotide) dosing, mechanism of action, side effects, and clinical evidence. Complete reference for healthcare professionals.

💉 IV infusion, subcutaneous injection📊 500-1000mg IV or 100mg subcutaneously📋 Moderate Evidence

Last updated: 2026-03-27

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Overview

NAD+ is a critical coenzyme involved in cellular metabolism, DNA repair, and sirtuin activation. Levels decline significantly with age.

Mechanism of Action

SIRT1 activation — Activates sirtuins for longevity pathways
DNA repair — Essential substrate for PARP enzymes
Mitochondrial function — Supports electron transport chain
Cellular energy — Critical for NAD+/NADH redox reactions

Dosing

IV: 500-1000mg over 2-4 hours. Subcutaneous: 100mg daily. Oral precursors (NMN/NR) also used.

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