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MOTS-c

Metabolic

MetabolicEvidence-based

MOTS-c

MOTS-c dosing, mechanism of action, side effects, and metabolic/longevity benefits. Mitochondrial-derived peptide reference.

💉 Subcutaneous injection📊 5-10mg, 3x weekly📋 Preclinical

Last updated: 2026-03-27

🏷️

Category

Metabolic

💉

Route

Subcutaneous injection

📊

Dosing

5-10mg, 3x weekly

📋

Evidence

Preclinical

🏥

Availability

available

Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide encoded by mitochondrial DNA. It plays key roles in metabolic regulation and has been studied for exercise-mimetic and anti-aging effects.

Mechanism of Action

AMPK activation — Activates AMP-activated protein kinase, enhancing cellular energy metabolism
Insulin sensitivity — Improves glucose uptake in skeletal muscle
Exercise mimicry — Produces metabolic effects similar to physical exercise
Folate cycle regulation — Modulates AICAR levels and purine biosynthesis

Dosing Protocols

Protocol	Dose	Frequency	Duration
Standard	5mg	3x weekly	Ongoing
Loading	10mg	Daily (1 week)	1 week

Safety Profile

Preclinical data shows favorable safety. Human clinical data is limited.

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