RegenerativeEvidence-based
KPV
KPV dosing, mechanism of action, side effects, and clinical evidence. Complete reference for healthcare professionals.
💉 Subcutaneous injection, oral, topical📊 200-500mcg, 1-2x daily📋 Preclinical
Last updated: 2026-03-27
Overview
KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-MSH, retaining anti-inflammatory properties without pigmentation effects.
Mechanism of Action
- NF-κB inhibition — Blocks inflammatory signaling pathways
- Gut healing — Reduces intestinal inflammation and promotes mucosal repair
- No pigmentation — Unlike full alpha-MSH, does not stimulate melanocytes
- Wound healing — Accelerates tissue repair
Dosing
200-500mcg subcutaneously or orally, 1-2 times daily. Topical for skin inflammation.
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