Hormone OptimizationEvidence-based
Epithalon
Epithalon dosing, telomerase activation, side effects, and anti-aging benefits. Synthetic tetrapeptide reference guide.
💉 Subcutaneous injection (SC, IM)📊 5-10mg daily for 10-20 day cycles📋 Preclinical
Last updated: 2026-03-27
Overview
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural epithalamin produced by the pineal gland, studied for telomerase activation and potential anti-aging properties.
Mechanism of Action
- Telomerase activation — Stimulates telomerase activity in human cells
- Melatonin regulation — Normalizes melatonin secretion from the pineal gland
- Cellular senescence — May delay cellular aging processes
- Antioxidant effects — Reduces oxidative stress markers
Dosing Protocols
| Protocol | Dose | Duration | Route |
|---|---|---|---|
| Standard | 5-10mg daily | 10-20 days | Subcutaneous |
| Cycling | 10mg daily | 10 days on, 20 days off | Subcutaneous |
Safety Profile
Limited human data. Used in Russian clinical practice. Generally well tolerated with few reported side effects.
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