Becaplermin

Regenerative

RegenerativeEvidence-based

Becaplermin dosing, mechanism of action, side effects, and clinical evidence. Complete reference for healthcare professionals.

💉 Topical gel (Regranex)📊 Applied once daily to wound📋 FDA Approved

Last updated: 2026-03-27

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Overview

Becaplermin (Regranex) is a recombinant human platelet-derived growth factor (PDGF-BB) in gel form for treating diabetic neuropathic ulcers.

PDGF-BB activity — Stimulates chemotaxis and proliferation of monocytes, neutrophils, and fibroblasts
Granulation tissue — Promotes formation of new granulation tissue
Wound healing — Accelerates closure of chronic wounds
Angiogenesis — Promotes new blood vessel formation in wound bed

Applied once daily to wound bed, covered with saline-moistened gauze. Calculate dose based on ulcer size.

FDA-approved with boxed warning regarding increased risk of cancer mortality with three or more tubes.

Beräkna sprutenheter och dosering från frystorkade peptider

Beräkna dosen baserat på patientens vikt och protokoll för mcg/kg

Uppskatta steady state, doseringsintervall och clearance-fönster

Konvertera mellan mikrogram, milligram, IU och sprutenheter

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